Age-Dependent Decrease in Platelet Aggregation in Rats.
نویسندگان
چکیده
منابع مشابه
P-selectin-dependent platelet aggregation and apoptosis may explain the decrease in platelet count during Helicobacter pylori infection.
P-selectin expression has been shown in Helicobacter pylori-infected persons, an infection that has been clinically associated with platelet-related diseases, such as idiopathic thrombocytopenic purpura. However, the role of P-selectin expression during H pylori infection remains unclear. In this study, we hypothesized that P-selectin expression was associated with platelet aggregation during H...
متن کاملIdentification of a Two-Stage Platelet Aggregation Process Mediating Shear-Dependent Thrombus Formation Running Title: Shear-dependent Platelet Aggregation
Authorship Statement M.J. Maxwell designed and performed the majority of the research and experiments, and co-wrote the paper with S.P. Jackson. E. Westein collected and analysed data and assisted in manuscript preparation. W.S. Nesbitt collected data for figures 1 and 7. S. Giuliano collected data for figures 1 and 7. S.M. Dopheide collected data for figure 1. S.P. Jackson designed research, p...
متن کاملAge-Dependent Protein Aggregation Initiates Amyloid-β Aggregation
Aging is the most important risk factor for neurodegenerative diseases associated with pathological protein aggregation such as Alzheimer's disease. Although aging is an important player, it remains unknown which molecular changes are relevant for disease initiation. Recently, it has become apparent that widespread protein aggregation is a common feature of aging. Indeed, several studies demons...
متن کاملProspective Evaluation of Genetic Variation in Platelet Endothelial Aggregation Receptor 1 Reveals Aspirin‐Dependent Effects on Platelet Aggregation Pathways
Genetic variation in the platelet endothelial aggregation receptor 1 (PEAR1) gene, most notably rs12041331, is implicated in altered on-aspirin platelet aggregation and increased cardiovascular event risk. We prospectively tested the effects of aspirin administration at commonly prescribed doses (81, 162, and 324 mg/day) on agonist-induced platelet aggregation by rs12041331 genotype in 67 healt...
متن کاملCalcium-dependent synergistic interaction of platelet activating factor and epinephrine in human platelet aggregation.
AIM To investigate the mechanism (s) involved in the synergistic interaction of platelet activating factor (PAF) and epinephrine. METHODS Blood was obtained from healthy human subjects reported to be free of medications for at least two weeks before sampling. Aggregation was monitored at 37 oC using Dual-channel Lumi-aggregometer. The resulting aggregation was recorded for 5 min by the measur...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biological and Pharmaceutical Bulletin
سال: 1994
ISSN: 0918-6158,1347-5215
DOI: 10.1248/bpb.17.1124